R2 ImageChecker CAD

Sophisticated CAD Solutions for Advanced Workstations



R2 ImageChecker® computer aided detection (CAD) for digital mammography is designed to offer the highest levels of detection performance, in combination with flexible workflow options. R2 ImageChecker offers advanced tools such as pinpointing regions-of-interest and increased flexibility for radiologists reading preferences. CAD marks can be easily toggled on and off with the press of a button on the digital mammography workstation. And, with a range of software options already available for the next generation of workstations, this software is ready for the future. Developed to deliver powerful detection performance on full-field digital mammography (FFDM) images, ImageChecker provides the lowest false marker rate at any given sensitivity level.


RightOn™ High Precision CAD Marks

RightOn CAD marks are designed to pinpoint regions-of-interest, efficiently drawing the radiologist’s eye to important image features. Calcification clusters are marked with the familiar R2 triangle and masses are marked with the R2 asterisk. The Malc™ mark flags regions containing prominent features of both mass and calcifications.

Citra™ For Earlier Detection, and Better Results

Citra, Hologic’s powerful new suite of advanced CAD tools for digital mammography, includes a series of increasingly detailed views of R2 ImageChecker CAD results. Citra tools include anatomic structure indications and numerical assessments of clinical features that not only increase CAD reading workflow efficiency, but also provide more detailed information about what CAD detected. In instances where a CAD mark is not easy to dismiss, exploring Citra’s additional information may make it apparent that a particular mark is false.

EmphaSize™ Variable Size CAD Marks

EmphaSize2 marks are displayed in variable sizes correlating to the prominence of features of a mass or calcification cluster. When the algorithm determines that a region contains more prominent features, the CAD mark appears larger. ImageChecker CAD evaluates each region of interest by examining several key characteristics including signal intensity, number of calcifications in a cluster, and shape of the calcifications. For masses, the algorithm evaluates key characteristics such as degree of spiculation, lesion shape, contrast to surrounding tissue, texture of lesion interior, and edge texture. As the prominence of these features increase, the algorithm enlarges the size of the mark. If a region contains both a mass and calcifications, ImageChecker CAD produces a Malc mark and scales the mark depending upon the prominence of both mass and calcification features.

PeerView™ Digital CAD Marks

PeerView Digital is an exclusive innovation designed to help the radiologist understand why the ImageChecker CAD algorithm marked a particular region. PeerView Digital outlines the suspicious region to help the radiologist visualize and analyze the specific structures that may warrant closer review. PeerView Digital outlines the central density of a detected mass or distortion so the radiologist can evaluate the margin, shape and interior characteristics. Detected microcalcifications are highlighted so the radiologist can determine the number, shape and distribution.

LesionMetrics™ Detailed Lesion Hightlights

LesionMetrics provides additional information about each region,including the prominence of certain features that are keyto the algorithm. For example, it measures the position of the lesion within the breast, and indicates values such as the fraction of lesion margin considered spiculated.

Breast Geometry Anatomic Segmentation

Breast Geometry provides gross assessment of breast outline and nipple position so that advanced workstations can provide sizing logic based on breast tissue in the image, optimizing the display of current and prior mammograms.


Extensive Clinical Validation

R2 CAD is the only mammography CAD system that has been clinically validated via prospective studies to significantly improve detection performance without a significant increase in workup rates. Improvement in radiologist performance using R2 CAD was first demonstrated via a prospective clinical trial published in 2000. Including Freer’s paper, a total of 5 independent, prospective peer-reviewed clinical studies from academic and community practices have shown that the use of ImageChecker CAD resulted in the detection of 4.7 percent to 19.5 percent more cancers.

More than 30 additional peer-reviewed papers and abstracts further validate the performance of ImageChecker mammography CAD. A prospective study stated the detection rates for small, invasive breast cancers (1.0 cm or less) increased by 164% when radiologists used R2 ImageChecker to assist in reading mammograms. Further, the mean age at screening detection of cancer with R2 CAD was 5.3 years younger than in those cases where CAD was not used.

About the Manufacturer


Hologic, Inc. is a leading developer, manufacturer and supplier of premium diagnostic products, medical imaging systems and surgical products, with an emphasis on serving the healthcare needs of women. The Company operates four core business units focused on breast health, diagnostics, GYN surgical, and skeletal health. With a comprehensive suite of technologies and a robust research and development program, Hologic is committed to improving lives. The Company is headquartered in Massachusetts.

Hologic employs approximately 5,500 employees worldwide. The Company's Common Stock is listed on the Nasdaq Global Select Market under the trading symbol "HOLX".